TILT; toxicant-induced loss of tolerance

In regard to “Toxicant-induced loss of tolerance (TILT)”

The following copy on TILT was posted in 2005 to an egroup that I am a member of, and my response to this post is below:

The National Institute of Environmental Health Sciences (NIEHS) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), components of the National Institutes of Health, are co-sponsoring the following conference:

Addiction and Chemical Intolerance: A Shared Etiology?


September 19 & 20, 2005 National Institute of Environmental Health Sciences (NIEHS) Rall Building Research Triangle Park, NC

Goal: NIEHS and NIAAA will bring together leading researchers to compare and contrast what is known in the fields of chemical intolerance and addiction and explore a new disease mechanism referred to as “Toxicant-induced loss of tolerance (TILT).” TILT has the potential to explain the etiology of a wide range of chronic health problems, including certain illnesses, in the following categories:

1. Respiratory illnesses such as asthma and rhinosinusitis

2. Neurological conditions like depression, bipolar disorder, autism, ALS, migraine headaches and attention deficit/hyperactivity disorder

3. Autoimmune diseases and rheumatologic conditions such as lupus, rheumatoid arthritis, chronic fatigue and fibromylagia

4. Gulf War “syndrome”

5. Addictive responses (cravings, withdrawal symptoms) in response to a wide variety of substances, including caffeine, alcohol, foods (obesity), as well as drugs and chemical pollutants

6. Individual variation in susceptibility to toxicants, drugs, implants, etc.

The conference will explore TILT’s origins, its relationship to addiction, the clinical parallels between addiction and chemical intolerance (or “abdiction”), new animal models, genetic polymorphisms, and neuroimaging studies that are underway in this rapidly emerging area.

Who should attend: Toxicologists, environmental health scientists, physicians, public health policymakers, and addiction researchers.

Agenda and Registration: Registration is free of charge and those interested in attending are urged to register in advance on the website:


My post in reply:

Dear (name removed):

I wish to thank you for this post on “Toxicant-induced loss of tolerance (TILT).”

Depending on how conventional medicine proposes to treat TILT, this could mean a real breakthrough for alternative medicine. I am very curious to see how this is going to go, “their way” (treat TILT with drugs), or “our way” (treat TILT naturally with nutrients and other natural measures).

It sure is nice to see modern conventional medicine finally beginning to address at least one of the ONLY three classes (nutrients, allergens, and toxins) of chemical influence on all cell function.

In reading about TILT a number of questions rather immediately came to my mind.

I wonder how long it is going to take modern medicine to address the other two classes of chemical influence on cell function (nutrients and allergens).

How much longer is modern medicine going to get away with ignoring the biologically and scientifically obvious? (Nutrients, of course.)

And how much longer is modern conventional medicine going to ignore the overwhelming anecdotal evidence in regard to allergens, especially food allergens?

How many tens of thousands (if not hundreds of thousands) of people is alternative medicine going to have to treat for multiple hidden food allergies before food allergy becomes part of the equation of conventional medicine?

Well, at least toxins may be becoming part of the equation (as per how I read your post to this egroup).

I wonder how modern medicine intends to treat “Toxicant-induced loss of tolerance (TILT).”

Are they going to treat TILT with drugs? Don’t they know yet that ALL drugs are toxic, every single one? To treat toxicant-induced loss of tolerance with any drug whatsoever sure seems ludicrous to me.

Or are they going to accept the biological and scientific fact that all detoxification pathways in the body are nutrient dependent?

Is conventional medicine going to accept the fact that supplementing with “detoxification important nutrients” might be helpful?

And are they going to accept the role of glutathione, the master detoxification molecule in the body, when treating TILT?

When treating TILT is conventional medicine going to supplement with either this master detoxification molecule (glutathione) or its amino acid precursors (cysteine, glutamic acid, glycine)? Cysteine, glutamic acid, glycine are better absorbed than glutathione itself, as well as much cheaper.


Is conventional medicine going treat TILT in a manner that accepts the role that many other essential nutrient molecules play in detoxification pathways in the body?

Is conventional medicine going treat TILT in a manner that accepts the helpfulness of vitamin C when dealing with toxicity?

What about the helpfulness of water when dealing with toxicity? (“Part of the solution to pollution is dilution.” Sherry Rogers)

Is conventional medicine going to look at the “total toxic load” (another concept I learned from Sherry Rogers) of the body when dealing with TILT?

Is conventional medicine going to address the fact that by far the largest common burden of toxins in the body is located in the bowel (as per Bernard Jensen in “Tissue Cleansing Through Bowel Management”)?

Is conventional medicine going to address the fact that ANY and ALL intestinal dysbiosis issues, such as candida, other molds, yeasts, and fungi, various “bad bacteria”, and/or parasites, can place a large toxic load on the body… a toxic load that can be both physically and mentally crippling?

Is conventional medicine going to see the wisdom of reducing the total toxic load in the body when treating TILT, such that the body can have greater availability of detoxification molecules rather than having so many of them used up dealing with “bowel and other stuff”?

Is conventional medicine going to see the wisdom of liver cleansing as per http://www.curezone.com when dealing with TILT? The liver is the master detoxification organ in the body. Are they going to consider cleansing this organ? How about considering the need of the liver cells for essential nutrient support?

If the conventional medical model is finally going to have to admit to the key role that the three amino acids of cysteine, glutamic acid, glycine play in detoxification in the body, what about the other amino acids? Are they still going to get away with ignoring the other amino acids in regard to so much cellular, mental, and physical function as well?

Or is conventional medicine going to do the same thing with TILT that they do when treating all psychiatric illnesses… which is to assume that all psychiatric patients are nutrient replete, as well as assume that we are not too toxic or allergic at all? (I can’t believe that they continue to get away with this stuff, but they still do.)

Jees, what’s so important about amino acids? They are only 70% of the body’s remaining mass by weight once the water is taken out, as well as are key nutrient precursors to every or almost every neurotransmitter, hormone, enzyme, and detoxification molecule in the human body.

If TILT gets treated properly (as per some of the questions above), this may represent a huge breakthrough for the understanding and treatment of all mental illness in the future.

However, I am still a bit skeptic. It seems to me that there is no way amino acids, other nutrients, and the “total toxic load” could be important and regularly used when doctors treat TILT… at least that’s how I see conventional medicine is probably going to address this new illness. Or perhaps conventional medicine is going to address TILT only by the use of intravenous (IV) glutathione, which means that “we still have to come to them”, while doing everything that they can to take effective dosages of free form amino acids and other detoxification molecules off of the free market (as per CODEX).

Maybe I am wrong in regard to the skepticism reflected above. I sure hope so, for all our sakes.

Allen Darman


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s